Select Publications

1.   Differential Expresison of 3'UTR and Cognate CDS

a. Yang,Z., Ji, S., Gozali, L, Ullah, M,. Parsa, S., Behr, B., Hynes, M. (2022) . Differential expression of Nanog 3’UTR and coding region mRNA components defines an embryonic stem cell niche. bioRxiv 2022.03.15.484504.

b. Ji, S., Yang, Z., Gozali, L., Kenney, T., Kocabas, A., Park, C.J., Hynes, M. (2021) PLoS One 16 (5). Distinct expression of select and transcriptome-wide isolated 3’UTRs suggests critical roles in development and transition states.

c. Kocabas, A., Durate, T., Kumar, S., Hynes, M. Terence Duarte12†, Saranya Kumar1 and Mary Hynes. Widespread, cell-type specific differential expression of coding region and UTR sequences  Neuron. 2015

2. Hair follicle stem cells

a.     Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH Jr, de Sauvage FJ. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. 1998 Jan 1;391(6662):90-2. PubMed PMID: 9422511.

3. Dopaminergic neuronal specification  

a.     Hynes, M.A., Porter, J. A., Chiang, C, Chang, D., Tessier-Lavigne, M., Beachy, P.A., and Rosenthal, A.  (1995) Induction of Midbrain Dopaminergic Neurons by Sonic Hedgehog.  Neuron, 156, 35-44.

b.     Hynes, M.A., Poulsen K., Tessier-Lavigne, M., and Rosenthal, A.  (1995) Control of Neuronal Diversity by the Floor Plate: Contact-Mediated Induction of Midbrain Dopaminergic Neurons.  Cell, 80, 95-101.

c.     Ye, W-L., Shimamura, K., Rubenstein, J.R.L., Hynes, M.A*., and Rosenthal*, A.  (1998)  FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate.  Cell, 93, 1-20. (* = both authors are corresponding authors)

d.     Hynes, M.A., Stone, D.M., Dowd, M., Pitts-Meek, S., and Rosenthal, A. (1997) Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1. Neuron, 19, 15-27

4. Support by trophic factors

a.      Poulsen, K., Armanini, M.P., Klein, R.D., Hynes, M.A., Phillips, H., and Rosenthal, A.  (1995) TGF beta2 and beta 3 are Potent Survival Factors for Midbrain Dopaminergic Neurons.  Neuron, 13 (5), 1245-52.

b.     Hynes, M.A., Poulsen, K., Armanini, M., Berkemeier, L., Phillips, H., and Rosenthal, A.  (1994) Neurotrophin-4/5 is a Survival Factor for Embryonic Midbrain Dopaminergic Neurons in Enriched Cultures.  Journal of Neuroscience Research, 37, 144-154.

c.     Wang, L.-C., Shih, A., Hongo, J., Devaux, B., and Hynes, M.A. (2000) Broad Specificity of GDNF Family Receptors GFRa1 and GFRa2 for GDNF and NTN in Neurons and Transfected Cells. J Neurosci Res. 61,1-9.

5. Axonal guidance and induction of dopamine neurons from embryonic stem cells

a.     Li, J., Duarte, T, Kocabas, A, Works, M, McConnell, SK, Hynes, MA (2014) Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum. Molecular and Cellular Neuroscience 61, 85-96.

b.    Cord*, BJ, J Li*, Works M, McConnell SK, Palmer T and Hynes MA. (2010) Characterization of axon guidance cue sensitivity of human embryonic stem cell-derived dopaminergic neurons. Molecular and Cellular Neuroscience, 5, Issue 4, December 2010, 324-334

6. Development of Peripheral organs

a)     Cacalano G, Fariñas I, Wang LC, Hagler K, Forgie A, Moore M, Armanini M, Phillips H, Ryan AM, Reichardt LF, Hynes M, Davies A, Rosenthal A. GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron. 1998 Jul;21(1):53-62. PubMed PMID: 9697851; PubMed Central PMCID: PMC2710137.

b)    Jin SL, Hynes MA, Lund PK. Ontogeny of glucagon messenger RNA and encoded precursor in the rat intestine. Regul Pept. 1990 Jul 30;29(2-3):117-31. PubMed PMID: 2217900.

c)    Taraviras S, Marcos-Gutierrez CV, Durbec P, Jani H, Grigoriou M, Sukumaran M, Wang LC, Hynes M, Raisman G, Pachnis V. Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development. 1999 Jun;126(12):2785-97. PubMed PMID: 10331988.